"Makipag-usap" typically indicates the actor is [b]initiating[/b] the discussion with the person being talked to. Ex: "John talked to Mary," where John is the initiator of the discussion. This is different than "mag-usap" which indicates two people are having a discussion only.
Makipag-usap Example Sentences in Tagalog: (4)
Nakipag-usapakósa coordinator kanina.
I talked with the coordinator earlier today.
Nakíkipag-usapsi Peter kay Paul.
Peter is talking with Paul.
Nakíkipag-usapsi Mary kahit kanino.
Mary talks with anyone.
I don't want to talk to you.
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